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ROS regulates MAPK and NF-B signaling pathways, further affecting cell proliferation, angiogenesis, and apoptosis in joints (173)

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Under physiological conditions, the Neh2 structural domain of Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm, facilitating Nrf2 ubiquitination and subsequent degradation (32)

From systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) to MS and autoimmune skin disorders, the disruption of proteostasis not only amplifies disease pathology but also renders conventional therapies less effective