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Two to five percent niacinamide has proven to be an effective lightening agent for patients with melasma or UV induced hyperpigmentation [27-29]

doi: 10.1038/s41581-020-0267-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 2

In another study, lipopolysaccharide (LPS) (, serotype 0111:B4, 0.5 mg/kg b.w., i.p.) was used as an oxidative damage inducer in rats pre-fed fermented rooibos for 4 weeks