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247 In the circulating blood of patients with atherosclerosis and hypertension, the numbers of some exosomes containing miRNAs that can induce endothelial dysfunction are significantly increased, 248 which can increase the risk of atherosclerosis

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Notably, many tumors also express functional lipoprotein lipase and can harvest fatty acids from triglyceride-rich lipoproteins via two routes: (i) lipoprotein lipase -mediated extracellular hydrolysis with subsequent uptake (e.g., via the CD36 receptor) and (ii) a non-catalytic bridging mode in which the lipase tethered to heparan-sulfate proteoglycans interacts with very low density lipoprotein receptor family pathways to internalize lipoprotein particles 14,15,16,17,18,19