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Thioredoxin-interacting protein (TXNIP) plays an important role in oxidative stress and NOD-like receptor protein 3 (NLRP3) inflammasome activation

The factors considered responsible for the challenges in recognition and timely diagnosis of DPN include: a) the insidious course of disease manifesting with non-specific symptoms and signs mimicking many other diseases, b) a lack of consensus on optimal screening and diagnostic procedures, c) the absence of a well-established diagnostic scrutiny, and d) the poor acceptance of guidelines and insufficient awareness of the disease among physicians (30, 5658)

Ethical statement This is a review article

How to use At the last step of the skincare routine, get a moderate amount and apply it on the skin exposed to UV rays