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The attention for this compound was drawn by the findings of Carlton that cuprizone possesses various biotoxic effects in rodents like growth retardation, pregnancy disturbances, and severe CNS pathology, including demyelination, astrogliosis, and hydrocephalus (Carlton, 1966, 1967, 1969)

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Nevertheless, progress in understanding the mechanisms of ENS control of mucosal secretion and the function of secretomotor neurons in the submucosal division of the ENS has rendered this explanation incomplete