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Description

Xue and colleagues designed a nanogel enclosing ginsenoside CK within a pH-sensitive Schiff-base network, which exhibited minimal drug leakage at neutral pH yet quickly degraded in acidic environments, thereby enhancing its cytotoxicity against lung cancer cells in vitro (Xue et al., 2021) (Figure 6)

In vitro, Fun30 protein lacking the SAM-key is able to bind nucleosomes but is deficient in DNA-stimulated ATPase activity and nucleosome sliding and eviction