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this explains the findings of this study, where tissue levels of the selected pro-inflammatory mediators were all elevated in BLM-only-treated animals, proving the fact that BLM caused significant alveolar epithelial damage that initiates a phase of acute inflammatory response in which innate immunity is the main player, especially during the first week of the induction followed by the activation of the adaptive immunity and the release of important cytokines to activate and propagate fibrosis of the pulmonary architecture 12

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