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Although several in vitro studies have demonstrated that SSRI increase aromatase activity and estradiol synthesis 18,19,20,36,37 , in vivo studies have conflicting results with increased or decreased estrogen synthesis and signaling 23

Songs research on non-small cell lung cancer (NSCLC) found that there is ferroptosis in cancer cells treated with cisplatin, and ferroptosis-resistant cancer cells could secrete miR-4443 through exosomes, which increase the expression of FSP1 in ferroptosis-sensitive cancer cells, thereby enhancing the resistance of the cancer cells to ferroptosis [29]