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Somalogic probe validation Somalogic has analysed close to 1 million samples with their technology at the time of this publication, resulting in some 700 publications ( There is minimal replicate sample variability 64,65 (coefficient of variation, CV)

S-COMT is found in the liver, intestine and kidney (Taskinen et al., 2003), whereas the MB-COMT is more highly expressed in the central nervous system (Tunbridge et al., 2006)

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The downregulation of SOD and upregulation of genes like MPO and HIF1 support this oxidative stress-driven mechanism