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have demonstrated equivalent activity after lyophilization and reconstitution of O 2 -tolerant [NiFe]-hydrogenases to freshly isolated enzyme, indicating that metal cofactors and amino acid side-chains responsible for proton/electron transfer were not altered by lyophilization 36

doi: 10.1038/npp.2010.105 151 WilkinsonMBDiasCMagidaJMazei-RobisonMLoboMKKennedyPet al

Get out or die trying: peptide- and protein-based endosomal escape of RNA therapeutics

Head-to-Head Comparison The most direct comparison came from the SURMOUNT-5 trial, which evaluated tirzepatide compared to semaglutide in adults with obesity