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Description

7 , eabm2508 (2022)

Zinc promotes Treg differentiation by inhibiting the activity of Sirtuin 1 (Sirt1), an enzyme that deacetylates Foxp3, a modification that leads to its ubiquitination and subsequent degradation

Bustos, J

The first two bind to the xenobiotic response element (XRE) sequences, while the last binds to the NF-B binding site in the NFE2L2 promoter, inducing its transcription [171,172,173,174], with a consequent increase of NFE2L2 mRNA available within the cell