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This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

B6 is a rate limiting cofactor in the synthesis of several neurotransmitters such as dopamine, serotonin, -aminobutyric acid (GABA), noradrenaline and the hormone melatonin (1)

None of the Marketing Authorisation Holders in the UK use any clinical evidence for optimal dosage of 3 monthly treatment and base the information written in their Patient Information Leaflet upon BNF Guidelines and the Martindale Drug Reference book