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Reports have found that astrocytes have a greater ability than neurons to take up glutamate, potentially because astrocytes can maintain a more stable membrane potential with high extracellular Na + and low K + compared to neurons, and neuronal firing makes neurons have a less stable Na + /K + ratio (Mahmoud et al., 2019)

Interferon-, which shifts the cytokine balance toward an anti-inflammatory profile, is one of the first treatments shown to reduce relapse rates in relapsingremitting MS [112]