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Notably, amyloid deposits in ATTR patients correlate with markers of lipid peroxidation, such as 4hydroxytrans2nonenal (HNE) adducts [35] and oxidative DNA damage indicated by 8hydroxy2deoxyguanosine (8OhdG) [34]

Djalali et al

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimers disease neuropathology: redox proteomics analysis of human brain