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Urolithins are anti-oxidative and anti-inflammatory metabolites produced by gut microflora from dietary ellagitannins, which are polyphenolic compounds derived from ellagic acid and are rich in some fruits and nuts such as pomegranates, raspberries, walnuts, almonds, etc

Keeping the dopamine agonist dose as low as possible, using longer acting dopamine agonists such as the rotigotine patch and maintaining a high serum ferritin level may help prevent the development of augmentation

It also replenishes essential nutrients that are needed in the body for further biological actions

To prevent metabolite inter-conversion the ice-cold samples were centrifuged within 15 min of the blood collection and the plasma stored at 80 C until analysis within 2 weeks