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That gap in knowledge leads to: Over 1 million ER visits each year due to adverse drug reactions More than 100,000 deaths annually the 4th leading cause of death in the U.S

3.5.2 Activation of the Keap1Nrf2 pathway and detoxification ITCs are potent activators of the Keap1Nrf2 signaling pathway, which upregulates cytoprotective genes

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Canagliflozin significantly inhibits inflammatory factor expression, including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase, exerting cardioprotective effects by regulating inflammation and ferroptosis through the AMP-activated protein kinase (AMPK) pathway (83)