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Charo MF, Goethel G, Brucker N et al (2019) Melatonin-loaded lipid-core nanocapsules protect against lipid peroxidation caused by paraquat through increased SOD expression in Caenorhabditis elegans

doi: 10.1016/j.tins.2012.11.005 42

doi: 10.1089/ars.2021.0048 54 SunTPikiolekMOrsiniVBerglingSHolwerdaSMorelliLet al

However, rational optimization of these lipids remains challenging because of the complexity of LNP systems and the limited understanding of how lipid structure influences both efficacy and long-term safety