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Structure of EBOV polymerase in a distinct conformation As mentioned above, the overall architecture of the (LVP35) E Core comprising only the core region of EBOL within the construct is similar to the published EBOV LVP35 structures in the apo state (PDB: 7YER and 7YES) or in complex with a 10 nt 3-leader RNA (PDB: 8JSL), in which full-length EBOL proteins were included for structural determination 8,9