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Functional annotation clustering of the dysregulated genes in the JUUL WT mice highlighted down-regulation of several genes related to immune responses and immunoglobulin production ( Ccl19, Igkv3-7, Igkv4-59, Igkv8-16, Fcgbp ), mucin secretion ( Muc5ac and Muc5b ), basal cells ( Krt5 and Krt15 ), as well as metal-binding, particularly iron ( Obscn, Tnnc1, Nr1i2, Cyp2a5, Ltf, Nrap, Zfp82, Fbxo40, Reg3g, Fer1l6, Clca1, Em2 ) (Additional file 1: Table S1)

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