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but note that several studies have suggested that D2-MSNs may also contribute to reward-based motivation 6365 and that MSN subtype-specific actions may depend on different patterns of activation 66 ]

This finding appears to be reasonable, considering the substantial inter-individual variability in female hormones 12,63

Ethical approval and consent to participate The experiments in this study used established human (MKN45, MKN74 and SNU-16) and mouse (3T3-L1 MBX) cell lines