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The reliability of the available data is moderate but uneven across compounds: ALA is supported by extensive experimental and clinical studies, UA by strong mechanistic and animal evidence with emerging human trials, and EGT mainly by cellular research and epidemiological observations

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A.MenkirA.UnakchukwuN.MesekaS.FarinolaA.GirmaG.et al

PQ 2+ is a redox cycling compound that takes electrons from the electron transport chain or NADPH and, via its cationic radical, reduces molecular oxygen to the superoxide radical O 2