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High doses of PQQ shown preventive effects against hypoxic/ischemic damages, seizures induced by chemical agents, inflammation from carrageenan, ethanol or carbon tetrachloride (CCl 4 )-induced liver damage, cataract formation, glutathione depletion in glucocorticoid-treated chicken embryos, and endotoxin-induced death in in vivo models (He et al., 2003

However, considering therapeutic strategies that target cancer cell metabolism alone is not sufficient because metabolic rewiring affects the composition, phenotype and function of cancer cells and microenvironmental components

doi: 10.3389/fcell.2021.690306 84 NeelBGTonksNK

This is why a 500 mg dose in a liposomal format is often far more impactful than a much higher dose in a standard tablet