glutathione pyruvate dehydrogenase Deficiency The Multifaceted Pyruvate Metabolism: Role

The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier Item Scheme showing the enzymatic reactions that catalyze the pyruvate dehydrogenase complex, including pyruvate dehydrogenase activity and diaphorase activity of DLD (A) as well as the glutathione reductase peroxidase activity (B). Glutathionylation of pyruvate dehydrogenase complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress ScienceDirect Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions: Cell Reports

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