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Additionally, the modified icaritin isopentenyl derivative C3 induces cell apoptosis and cell cycle arrest at S phase in multiple myeloma (RPMI 8226), while another semi-synthetic derivative 11c inhibits the proliferation of liver cancer (Hep G2 and SMMC-7721) cells by inducing cell apoptosis and cell cycle arrest at G0/G1 phase [770, 771]

10.1016/j.preteyeres.2006.07.003 136 TezelG.WaxM

Sorci, F

These observations underscore an important therapeutic implication for MASLD, showing that the timing and disease stage may be critical for maximizing the protective effects of GSH depletion, with the greatest benefit likely occurring during early, lipogenesis-driven phases of MASLD progression