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SIRT5 Deficiency enhances susceptibility to Kainate-Induced seizures and exacerbates hippocampal neurodegeneration not through mitochondrial antioxidant enzyme SOD2

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Fluctuations in copper homeostasis during HF may disrupt mitochondrial function and exacerbate oxidative stress (66)

Eligible participants were then invited to attend the sleep clinic for a comprehensive sleep assessment by a sleep physician or sleep psychologist who diagnosed Insomnia Disorder using DSM-5 1 , with participants having difficulty initiating or maintaining sleep or waking up too early for at least three nights per week and greater than three months, with adequate opportunity for sleep coupled with daytime impairment related to the sleep difficulty