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Indeed, a single usual amount (i.e., 200250 mL juice or a whole grapefruit) has sufficient potency to cause a pertinent pharmacokinetic interaction.8 , 11 , 12 For example, felodipine combined with such a quantity of grapefruit had an average systemic drug concentration that was 3-fold that seen with water.8 , 11 With twice the amount of grapefruit, there was only a modestly greater increase in the systemic concentration of felodipine, showing that a near-maximal pharmacokinetic interaction had already occurred with the consumption of the single quantity.11 With repeated ingestion of grapefruit (250 mL of juice, 3 times/d for 6 d), a single dose of felodipine increased to 5 times the systemic concentration seen with water, suggesting that frequent consumption of a usual quantity daily augmented the pharmacokinetic effect moreso than the lone quantity.8 The interval between the ingestion of grapefruit and the adminstration of the interacting drug has some effect on pharmacokinetics

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