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Adult dogs receiving the tablet formulation for 30 consecutive days at a daily treatment of 25 mg/kg did not exhibit significant clinical signs nor were there effects upon the clinical chemistry, hematological or histological parameters

We highlight sulforaphane as an exemplar with robust human PK/PD dataincluding mercapturic-acid metabolites, LCMS/MSquantified conjugates, and Nrf2 target gene inductionand contrast this with the instability and limited systemic detectability of thiosulfinates such as allicin

At the end of the experiment, animals were killed and tumour, kidney and liver were collected, fixed and paraffin-embedded for histology

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