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This inhibition causes AICAR to accumulate intracellularly

Moreover, a significant fraction of subjects, commonly referred to as treatment-resistant, do not respond to these antidepressants despite the use of various therapeutic strategies (173)

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Acetaminophen Injection - Clinical Pharmacology 12.1 Acetaminophen Injection Mechanism of Action The precise mechanism of the analgesic and antipyretic properties of acetaminophen is not established but is thought to primarily involve central actions