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AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

And this process is independent of other SGK1 target, the FOXO transcription factor DAF-16 and phase II ROS detoxification SKN-1/NFE2L2/NRF2 [62]

In all cases, stage L4 worms were used at t = 0 for lifespan analyses and worms were transferred every 23 days to new agar plates

Its core symptoms (extenuating fatigue, post exertional exacerbation, cognitive dysfunction, sleep disorders and pain) are shared with the other PAIS ( Table 1 , which will be described later, the term ME/CFS will point to long diseases in which the triggering pathogen is neither SARS-CoV-2 nor Borrelia (otherwise, they would be called long COVID or long Lyme)