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This accumulation of ROS disrupts cellular signaling pathways and structural integrity [156], contributing to the aging process and the development of age-related diseases, including DE

Involvement of histidine-91 of the beta subunit in proton translocation by the pyridine nucleotide transhydrogenase of Escherichia coli

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The present review investigates the dual roles of copper in AD, integrating the emerging concept of cuproptosis with classical A/tau hypotheses, and critically evaluates copper-targeted therapeutic strategies