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Bruckert, E

By understanding the "recycling" relationship between these two antioxidants, you can see why they are more effective as a pair than as solo players

[20,21] Overview of Cancer Therapeutic Agents Chemotherapy agents can be divided into several categories: alkylating agents (e.g., cyclophosphamide, ifosfamide), antibiotics which affect nucleic acids (e.g., doxorubicin, bleomycin), platinum compounds (e.g., cisplatin), mitotic inhibitors (e.g., vincristine), antimetabolites (e.g., 5-fluorouracil), camptothecin derivatives (e.g., topotecan), biological response modifiers (e.g., interferon), and hormone therapies (e.g., tamoxifen).The agents most noted for creating cellular damage by initiating free radical oxidants are the alkylating agents, the tumor antibiotics, and the platinum compounds

Among LOX inhibitors, Zileuton (A-64077), a LOX-5 inhibitor, reduces oxidative stress by regulating ROS levels in retinal pigment epithelial (RPE) cells, offering potential for retinal disease treatment (Liu et al., 2015