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demonstrated that a very significant part of high molecular weight (300 kDa) histidine-rich protein from rat epidermis is rapidly degraded by the epidermal proteinases, leading to the accumulation of a 56 kDa fragment (Kashima et al., 1988)

Trial candidates are generally adults with type 2 diabetes and a BMI over 30 who have not achieved adequate glucose or weight control with standard therapies like metformin or a single GLP-1 agonist

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