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Heat stress also upregulates genes associated with apoptosis ( BAX) , translation inhibition ( EIF4EBP1 ), and lipogenesis ( PPARG , FASN , and ACACA ) and decreases the expression of the anti-apoptotic gene BCL2L1 in the mammary glands of dairy cattle (109)

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In parallel, delivery technologies such as recombinant protein formulations, exosome purification and focused ultrasound should be evaluated in animal models [307, 308]