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In this randomized, placebo-controlled, double-blinded, parallel-arm design prospective trial, CIALIS demonstrated clinically meaningful and statistically significant improvement in erectile function, as measured by the EF domain of the IIEF questionnaire and Questions 2 and 3 of the SEP diary (see Table 15)

& Santamaria, P

Increased ROS levels trigger the upregulation of various antioxidant proproteins/enzymes, initiating a negative feedback mechanism to modulate stress signaling or ROS concentrations