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Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Vance ML

Only the 6-week levels were significantly different between the two groups.[23] Based on the 49 pmol/L (66 ng/L) difference in median milk levels reported at 6 weeks, exclusively breastfed infants would receive an extra 0.01 mcg/kg daily of vitamin B 12 from maternal 50 mcg once daily oral supplementation

Short-term protocols (1216 weeks) at standard doses carry minimal toxicity risk, but long-term use beyond 6 months lacks human safety data as of 2026