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Pro: Side effects are generally minimal and primarily center around the discomfort and unusual experience of using a suppository

PloS One (2012) 6:38947

Biochem Biophys Res Commun 301 : 516520

Upon exposure to GSH, redox-driven or binding-induced structural changes modulate their emission, enabling highly sensitive and selective GSH quantification with minimal interference from other thiols such as cysteine and homocysteine [93]