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In order to gain insights into biological pathways associated with increasing emphysema severity within a patient and explore computational strategies for identifying COPD therapeutics, we obtained paired samples from eight regions at regular intervals between the apex and base of each explanted lung from six patients with severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage IV) and two donor lungs

In our study, however we did not observe differences between the two groups

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Front Pharmacol 9:1162 Termini L, Fregnani JH, Boccardo E et al (2015) SOD2 immunoexpression predicts lymph node metastasis in penile cancer