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Arginine is either imported into cells through the cationic amino acid transporter CAT2B and hydrolyzed by intracellular arginase 1 [230] or directly hydrolyzed by extracellular arginase 1 in the extracellular compartment [231, 232]

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Ground leaching from landfills, agricultural runoff with fertilizers or pesticides, and mining sites, for instance, can also influence pH