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Informed Consent For this type of study informed consent is not required

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It provides protection against the damaging effects of a wide range of noxious agents, such as alcohol and nonsteroidal anti-inflammatory drugs (NSAIDs), which are known to cause significant tissue injury

In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression