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The thyroid glands of these patients were characterized by diffuse lymphocytic infiltration, fibrosis, parenchymal atrophy, and an eosinophilic change in some of the acinar cells.(1) Clinical and pathologic studies of this disease have appeared frequently since Hashimoto's original description

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In the second reaction, glycine is attached to the C-terminal of -EC and this reaction is catalyzed by glutathione synthase (GSH2, EC 6.3.2.3) forming the tripeptide reduced glutathione (GSH) (Meister 1988) (Figure 4.1)

NAC N-acetyl cysteine (NAC) helps decrease the severity and frequency of wheezing and respiratory attacks by boosting glutathione and thinning bronchial mucus, thus working as an effective asthma remedy