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These findings suggest that optimal NAMPT levels and activity are critical for healthy aging and overall organismal homeostasis, and both upregulation and targeted inhibition may offer potential interventions depending on the specific context and tissue

As shown in Table 1 and Figure 6, such inhibitors mainly include MvH45 (Van Haren et al., 2017), AK-12 (Ruf et al., 2022), MS2756 (Babault et al., 2018), MS2734 (Babault et al., 2018), GYZ-78 (Gao et al., 2019), NS1 (Kuzmi et al., 2021), LL320 (Chen D