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Mallik S

The defect leads to a multisystem disorder involving connective tissue, muscle, the central nervous system, and the cardiovascular system [2]

17 , e3000346 (2019)

IGF-1 LR3 is a modified analog of human Insulin-Like Growth Factor-1, engineered with two structural changes an arginine substitution and a 13-amino acid N-terminal extension that reduce its binding to IGF-1 binding proteins