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Oral administration forces any compound to travel through the gastrointestinal tract, be absorbed across the intestinal epithelium, and then pass directly to the liver via the hepatic portal vein before reaching the rest of the body

thus a deficiency may lead to disruption of DNA synthesis/cell metabolism and have serious clinical consequences

Beta-oxidation and beta-3 adrenergic signaling are selectively stimulated, enabling detailed studies of lipid metabolism and energy regulation

Symptoms of Vitamin B-12 Deficiency Fatigue and Weakness Low Moods Low Concentration Level Loss of Appetite Constipation Poor Memory Foods Rich in Vitamin B-12 Beef and chicken liver Wild-caught fish such as salmon, trout, and tuna Grass-fed beef and lamb Pasture-raised poultry Organic dairy products like milk and yogurt Who Is Most Likely to Have a Vitamin B-12 Deficiency