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Pettersson, P

Jamora explains

Typically, CAFs overexpress alpha-smooth muscle actin (-SMA), Vimentin, platelet-derived growth factor receptor (PDGFR), PDGFR, Tenascin-C, Caveolin 1, fibroblast activation protein (FAP), and ferroptosis suppressor protein 1 (FSP1) [66]

The risk of opioid-related overdose or overdose-related death is increased with higher opioid doses, and this risk persists over the course of therapy