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Mechanisms of Muscle Hypertrophy IGF-1 DES promotes muscle growth through potent activation of IGF-1 receptors on muscle cells, triggering PI3K/Akt/mTOR pathways mediating protein synthesis, increased amino acid and glucose uptake into myocytes, satellite cell activation and proliferation, inhibition of protein degradation (anti-catabolic effects), and enhanced muscle fiber hypertrophy

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"Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1." Cell Metabolism 37.2 (2025): 460-476

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