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This review systematically discussed the assembly, activation, and pathogenic contributions of the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in AP pathogenesis

The converse is also true, as blocking TCA entry of either carbohydrates or fats decreases NADPH and GSH, makes the ER more oxidizing, and diminishes ER stressan effect that can be phenocopied by inhibiting GR (Gansemer et al., 2020)