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Detachment of astrocytes and decreased expression of AQP-4 on the astrocytic endfeet cause water imbalance within the CNS (Erickson and Banks, 2019

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Scale weight can rise for reasons that have nothing to do with added body fat: Increased training volume more muscle glycogen and water Appetite shifts (up or down) Hydration changes as routines change Lean mass increases if training quality improves In other words, BPC 157 weight gain may reflect changes in training and recovery rather than a direct "stores fat" effect