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Expression of chemokine receptor type 4 (CXCR4) was found to be elevated in CD3 + T cells from Dj1 -deficient mice, suggesting that DJ-1 acts as an inhibitor of inflammatory cell recruitment

Additionally, severe ER stress accompanied by oxidative stress in response to MHO7 treatment led to the exposure of multiple DAMPs, including CRT, HMGB1, HSP70 and ATP, on the surface of TNBC cells

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Another efficacy end point was the odds ratio of patients achieving treatment success, defined by an improvement of 2 grades from baseline and/or reaching clear or almost clear on the IGA of acne severity