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39 41 Furthermore, there is a higher occurrence of excessive production of pro-inflammatory transcription factors and cytokines, which are significant contributors to the risk of colitis and development of CRC

A capsule can deliver plenty of peptide to the gut lumen, which is technically "available in the body" but not in systemic circulation

J Eur Acad Dermatol Venereol 2013

It remains unclear whether the observed increase in reactive oxygen species (ROS) drives the clinical manifestations, or if infection or the underlying conditions, such as obesity, are themselves responsible for elevating ROS levels