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The low response rate of lenvatinib, which is mostly caused by resistance development, limits its practical utility in treating patients with advanced liver cancer, even though it is the recommended initial treatment for this condition

Hernandez ML

177 HSP27 also facilitates STAT3 phosphorylation, either through IL-6 signaling or independently, leading to STAT3 nuclear translocation and its binding to the TWIST promoter

In contrast, the remaining three isozymes, GPx5, GPx7, and GPx8, are characterized as cysteine-containing proteins (CysGPx), where the active site selenocysteine is substituted with cysteine